23 Jul Micro-fluidic chip printing nozzle and biological 3D printing system
Abstract
A micro-fluidic chip nozzle comprises a micro-fluidic chip and a nozzle with a double-layer structure. The micro-fluidic chip comprises a micro-fluidic chip substrate layer and a micro-fluidic chip upper layer. The micro-fluidic chip substrate layer is provided with a plurality of flow channels and mixed-flow-structured flow channels. The mixed-flow-structured flow channels are connected with the outlet of the micro-fluidic chip, and micro valves corresponding to a plurality of flow channels are formed on the upper layer of the micro-fluidic chip; and the micro-valves can be controlled to be opened or closed so as to control liquid of the different flow channels to enter the mixed-flow-structured flow channels. The nozzle with the double-layer structure comprises an inner micro needle head and a shell, wherein the inner micro needle head is connected with the outlet of the micro-fluidic chip; and the shell is provided with a cross-linking liquid inlet and a nozzle outlet. A mixed solution fed from the inner micro needle head is mixed with cross-linking liquid fed from the cross-linking liquid inlet in the shell. Crosslinking produces gel fibers which exit from the nozzle outlet. The micro-fluidic chip nozzle structure of the invention is particularly suitable for printing a gradient tissue engineering cornea which has a layered structure.
Year: 2019
Country: CN
Doc No: 110257243