23 Jul Method of regulating degradation rate of porous collagen-based cradle with amino acid
Abstract
Amino acid with high biocompatibility is used as cross-linking and bridging agent, amino acid in 0.1-100 microns is made to compound with porous collagen-based cradle, and the cradle is further cross-linking treated with carbonated diimine compound, so as to prepare porous collagen-based cradle with controllable degradation rate and good biocompatibility. The present invention uses material withwide source, low cost and no toxic side effect; and the preparation process is simple, feasible, mild in condition and good in repeatability. The prepared porous collagen-based cradle can meet the requirement for different tissue and organ to regenerate and may be used widely in regeneration and reconstruction of skin, cartilage, bone, blood vessel, nerve, tendon, heart valve and other organs inbiomedicine, tissue engineering and other fields.
Year: 2003
Country: CN
Doc No: 1453044