23 Jul Method of Crosslinking of Polysaccharides Using Photoremovable Protecting Groups
Abstract
The invention discloses a method of preparation of crosslinked materials based on polysaccharides using electromagnetic radiation in an aqueous solution containing a polysaccharide with a bound carbamate photoremovable protecting group (PPG with group —NH—CO—O—) and a polysaccharide containing an aldehyde group —CHO. The crosslinking process itself is carried out by means of a condensation reaction of the photochemically released amino group (—NH2) with the aldehyde group (—CHO) forming a bond of imine type (—N═CH—). Both processes proceed simultaneously and they can be performed under physiological conditions. The advantage of the suggested solution is the temporal and spatial control of crosslinking that allows the preparation of advanced materials for tissue engineering where the crosslink density and thus the mechanical properties in the material structure can be tailored.
Year: 2018
Country: US
Doc No: 2018179302