23 Jul Method for preparing water soluble polyethylene glycol/polylactic segmented polycarbonate resin
Abstract
The invention provides a method for preparing a water soluble polyethylene glycol/polylactic segmented polycarbonate resin with thermal reversible gel effect by using solid phosgene as a coupling agent, which belongs to the technical field of water soluble polymer synthesis and degradable medical application. The method comprises the following steps that: under the catalytic action of stannous octoate, L-lactide is initiated to open by polyethylene glycol to synthesize a polylactic acid-polyethylene glycol-polylactic triblock copolymer containing a terminal hydroxy group; the triblock copolymer is subjected to chain extension by the solid phosgene to obtain polyethylene glycol/polylactic segmented polycarbonate resin; and the polyethylene glycol/polylactic segmented polycarbonate resin is precipitated and dried through a mixed solution of absolute methanol and absolute aether to obtain a viscous solid product. The copolymer has good water solubility and prominent reversible gel effect, and has wide application prospect in medicine slow release, tissue engineering and other fields.
Year: 2009
Country: CN
Doc No: 101531756