23 Jul Method for preparing rhizoma drynariae/pig bone powder/chitosan compound bracket material
Abstract
The invention adopts a method for preparing a medicated tissue engineering bracket material by a fully natural material, which overcomes the defects of slower growth of bone tissues at the initial period of implantation and weak synostosis at the initial period in the traditional tissue engineering bracket. The traditional Chinese medicines of rhizoma drynariae and pig bone type hydroxylapatite are introduced into the bracket to obtain a compound tissue engineering bracket material with excellent biological activity. The pig bone type hydroxylapatite is extracted from pig bones, has excellent biological activity and low production cost, is green and innoxious and is pulverized to reach a micron/nano state; the traditional Chinese medicine of the rhizoma drynariae has the functions of promoting the multiplication of osteoblast, accelerating the bone growth, diminishing inflammation and resisting bacteria and is prepared by an effective water extraction solvent method, a pulverization method and a spraying method; and the chitosan is used as a template and is prepared by a vacuum freeze drying method. The porosity of the bracket material is between 45% and 91%, the aperture is adjustable within a range of 40-500mu m, and the compressive strength can reach 0.1-5.6MPa. In the degradation process, the pH value of the bracket is between 6.77 and 7.50.
Year: 2010
Country: CN
Doc No: 101721744