23 Jul Method for preparing quaternary ammonium salt modified chitosan medicine-carried nano particles
Abstract
A preparation method of quarternary ammonium salt modified chitosan drug-loaded nanoparticle belongs to medical engineering field. The method comprises lead-in quaternary amine group to 6-hydroxy of chitosan under the protection of 2-amino to complete quaternary amine modification of C6-OH on chitosan and obtain quarternary ammonium modified chitosan, and wrapping under the existence of sodium tripolyphosphate at room temperature through controlling quarternary ammonium modified chitosan/ TPP of 6/1-3/1 to complete preparation of drug-loaded nanoparticle. The invention can be used as carrier material of macromolecular medicament to promote the molecule passing through tissue epithelia and increase absorption of macromolecular medicament in tissue; used for transporting micromolecular medicament; and has significant clinical application value and potential application.
Year: 2007
Country: CN
Doc No: 101085358