23 Jul Method for preparing Nisin/chitosan/polylactic acid composite nanofiber mats by coaxial electrospinning
Abstract
The invention discloses a method for preparing Nisin/chitosan/polylactic acid composite nanofiber mats by coaxial electrospinning. The method comprises the following steps: dissolving chitosan in an acetic acid solution, stirring and dissolving to prepare a chitosan solution; adding Nisin, stirring to prepare a Nisin/chitosan solution which is used as a shell spinning solution for coaxial electrospinning; dissolving polylactic acid in dichloromethane to prepare a polylactic acid solution which is used as a core spinning solution for coaxial electrospinning; and carrying out coaxial electrospinning on the shell spinning solution and the core spinning solution to prepare the Nisin/chitosan/polylactic acid composite nanofiber mat with Nisin and chitosan as the shell and with polylactic acid as the core. The method is simple and feasible, and cost is low. The prepared biodegradable bioactive antiseptic composite nanofiber mat can be used in the fields of wound dressing, tissue engineering and food package and the like, has excellent antibacterial effects, is safe and harmless, and will not cause drug resistance of bacteria.
Year: 2017
Country: CN
Doc No: 106668930