23 Jul Method for preparing neurone tissue engineered peripheral nerve
Abstract
The invention relates to the technical field of bioengineered tissue, the nerve bridging distance of the nerve around the tissue engineering constructed presently is not more than 30mm generally, the demand for repairing the deficiency of long-section nerve in clinic can not be satisfied, and the function of restoration after regeneration is not good. In the preparation method of the nerves around the neuron tissue engineering of the invention, hair follicle neural crest stem cells are selected for inducing the mixed cells of differential nerve-like Cells and the Schwann cells to be seeded cells in specific condition, which is constructed in the bracket of heterogeneity cell-removing nerve basilemma tube according to the proportion of 1:1. The nerves around the tissue engineering prepared by the invention can avoid regenerated axon exogenesis and error entering in growing process, thus shortening the time that the regenerated nerve fiber arrives at the effector, avoiding shrinking of the effector. Not only the demand for repairing the deficiency of long-section nerve in clinic is satisfied, but also the nerve function is restored well after the regeneration of nerves.
Year: 2008
Country: CN
Doc No: 101318031