23 Jul Method for preparing micro-grade polymer gel microspheres capable of loading protein
Abstract
The invention discloses a method for preparing micro-grade polymer gel microspheres capable of loading protein. In the invention, with polyethyleneglycol diacrylate as monomers, the micro-class polymer gel microspheres are prepared in a polysaccharide medium containing inorganic salts by adopting a dispersion polymerization method. The microspheres have favorable pelletizing state and better grain size dispersibility. The preparation process is simple and convenient and does not use any organic solvents, thereby avoiding causing the bioactivity reduction of loaded protein-based medicines or loaded cells. The micro-grade polymer gel microspheres are expected to load chondrocyte and growth factors for accelerating the chondrocyte to grow and are used for preparing injectable tissue engineering cartilage prosthesis.
Year: 2011
Country: CN
Doc No: 102010480