23 Jul Method for preparing mesh-shaped bionic bone porous stent material
Abstract
The invention relates to a method for preparing mesh-shaped bionic bone porous stent material, comprising the following steps: taking a multi-cellular marine animal natural sponge processed by organic acid and inorganic alkali solution as a template, impregnating with sol or water based slurry of hydroxylapatite, 45S5 bioactive glass, beta-tricalcium phosphate or calcium silicate, drying, oxidizing, demoulding and sintering at high temperature, thereby preparing the bone tissue engineering stent material in a mesh-shaped pore structure. The pore structural parameters and degradation performance of a porous stent are controlled by adjusting the solid content in the sol or the slurry, impregnation frequency and parameters in the process of oxidizing and demoulding as well as sintering at high temperature. Pore size of the mesh-shaped porous stent produced by adopting the invention is 100-300Mum, porosity is 68-94%, and the porous stent is highly similar to a natural cancellous bone in the shape and pore size. The product prepared by adopting the invention has the characteristics that bionic degree of the porous structure is high, adaptation to materials is high, process is simple and cost is low and the product has a great application potential in the regeneration repairing technology of hard tissue engineering, such as bone, basibranchial bone and teeth.
Year: 2011
Country: CN
Doc No: 102058902