23 Jul Method for preparing hydrogel by enzymatic free radical polymerization
Abstract
The invention relates to a method for preparing hydrogel by enzymatic free radical polymerization. According to the method, peroxidase, a beta-dicarbonyl compound and hydrogen peroxide are combined as an enzymatic free radical initiating system for providing free radicals for polymerization. The method comprises the following steps of: uniformly mixing an aqueous solution containing the peroxidase, the beta-dicarbonyl compound and alkene monomers in a using process; and then, adding hydrogen peroxide in the aqueous solution, adjusting the component concentration of a peroxidase/beta-dicarbonyl compound/hydrogen peroxide ternary initiating system, and controlling to obtain the hydrogel within 20 seconds to 30 minutes under the room temperature. The method for preparing the hydrogel by enzymatic free radical polymerization is realized in a water phase, gentle in reaction condition, simple and convenient to operate, quick and controllable in hydrogel forming time and capable of preparing the high-strength nanometer composite hydrogel material, and therefore, the method has an obvious application prospect in the fields including immobilized enzyme carriers, medicament controlled release, artificial cartilages, tissue engineering scaffold materials and the like.
Year: 2013
Country: CN
Doc No: 103342823