23 Jul Method for preparing growth-factor bound thermo-sensitive hydrogel biocarrier
Abstract
The invention discloses a method for preparing a growth-factor bound thermo-sensitive hydrogel biocarrier. According to the method, gamma-polyglutamic acid (gamma-PGA), taurine and N-isopropylacrylamide are used as main raw materials, N,N-methylene bisacrylamide (MBAA) is used as a crosslinking agent, ammonium persulfate or potassium peroxodisulfate is used as an initiator, and N,N,N’,N’-tetramethylethylenediamine (TEMED) is used as an accelerant. A semi-interpenetrating network technology is mainly adopted in the invention, and the preparation method comprises four steps: synthesizing a gamma-PGA-S72 monomer, preparing a thermo-sensitive hydrogel biocarrier, purifying the thermo-sensitive hydrogel biocarrier, and binding the thermo-sensitive hydrogel biocarrier and the growth factor.The growth-factor bound thermo-sensitive hydrogel biocarrier is rich in raw material source and simple in preparation method, has excellent biocompatibility, and has a wide application prospect in tissue engineering scaffolds, bio-medicinal carriers, bio-adhesives, wound dressing and other biological medical treatment fields.
Year: 2014
Country: CN
Doc No: 103948962