23 Jul Method for preparing dual-sensitivity graft copolymer with chitosan as main chain
Abstract
The invention belongs to the field of polymer material and biomedical engineering and particularly relates to a method for preparing dual-sensitivity amphipathic graft copolymer with chitosan as the main chain. The method comprises the following steps: with the protection of inert gases such as nitrogen and argon, hydroxide group or aminogroup in chitosan main chain are adopted to carry out esterification reaction with bromine-containing compound; the hydroxide group or aminogroup are converted into the bromine group; then the bromine group is taken as macroinitiator to polymerize atomic transfer radical of methacrylic acid-N and N-dimethylamino-ethyl methylacrylate monomer to form polymer featuring dual sensitivity of temperature and pH value, thus finally obtaining the dual-sensitivity graft copolymer with chitosan as the main chain. The dual-sensitivity graft copolymer with chitosan as the main chain is provided with biological degradability, biocompatibility, biological activity and pH value sensibility, can be automatically assembled into stable nano micelle in water, thus enjoying wide application in fields such as drug controlled release carrier, soft tissue engineering support material, immunoassay, memory element switch, biosensor and the like. The synthetic method of the invention is simple and feasible, the raw materials can all be applied to industrialized production, thus enjoying very good value in popularization and application.
Year: 2009
Country: CN
Doc No: 101580568