23 Jul Method for preparing dual-network hydrogel capable of orthogonally regulating mechanical property and drug release property
Abstract
The invention discloses a method for preparing dual-network hydrogel capable of orthogonally regulating the mechanical property and the drug release property through photo-crosslinking. The method includes the steps that firstly, polyacrylic acid and monoamino beta cyclodextrin serve as reactants to prepare polyacrylic acid powder grafted with beta cyclodextrin; secondly, the polyacrylic acid powder grafted with beta cyclodextrin is dissolved in a phosphoric acid buffer solution, and acrylamide, N’N-methylene bisacrylamide and a photoinitiator are added, and after the materials are uniformly stirred and mixed, cross-linking is conducted under ultraviolet. The method is simple in process, short in preparation period, controllable in size, high in repeatability and good in stability. The mechanical property of the prepared double-network hydrogel and the release property to polypeptides and other drugs can be orthogonally regulated and do not interfere with each other. The one-weight network controls the mechanical strength by adjusting a polymer network, and the one-weight network regulates controlled release by adjusting the affinity with drug molecules. The double-network hydrogel has a wide application prospect in the aspects of biological medicine, tissue engineering and the like.
Year: 2017
Country: CN
Doc No: 107056983