23 Jul Method for preparing different particle sizes of porous beta-TCP microspheres by oil-in-water type solid emulsification
Abstract
The invention discloses a method for preparing different particle sizes of porous beta-TCP microspheres by oil-in-water type solid emulsification. The method includes the steps of subjecting a calcium nitrate solution and a hydrogen phosphate solution to mixed reaction to obtain a hydroxyapatite precursor, dispersing the hydroxyapatite precursor into a polyvinyl butyral-dichloromethane solution to obtain a mixed solution, subjecting the mixed solution and a polyvinyl alcohol solution to mixed reaction to obtain precursor microspheres, and sintering to obtain a target product, namely the porous beta-TCP microspheres. The method has the advantages that the particle size of the microspheres is controlled through oil-phase concentration and a rotation speed, and the prepared beta-TCP microspheres are porous, controllable in size and excellent in biocompatibility and can be applied to the field of biological materials such as bone tissue engineering.
Year: 2017
Country: CN
Doc No: 106890606