23 Jul Method for preparing cross-linking agent modified hyaluronic acid-polyaspartic acid in-situ cross-linking type hydrogel
Abstract
The invention discloses a method for preparing cross-linking agent modified hyaluronic acid-polyaspartic acid in-situ cross-linking type hydrogel. According to the method, a modified cross-linking agent which is a substance with dialdehyde radical or diamine radical is added into a buffer solution successively or simultaneously to gelatinize polyaspartic acid derivative with dialdehyde radical and hyaluronic acid derivative with diamine radical through a condensation reaction. The hydrogel has the advantages of controllable mechanical strength, short gelatinization time, stable performance, good biocompatibility and biodegradation, and can be used in the fields of tissue engineering, embolism materials and medicine controlled-release by virtue of an injection means.
Year: 2014
Country: CN
Doc No: 103554528