23 Jul Method for preparing bone tissue engineering scaffold material
Abstract
The invention discloses a method for preparing bone tissue engineering scaffold material and belongs to the field of biomedical material technical application. According to the method, gelatin is dissolved in deionized water under magnetic stirring to obtain gelatin hydrosol, then modified nano-hydroxyapatite and stearic acid microspheres are added into the hydrosol and evenly stirred and cooled for a certain period of time, and scaffold pug is obtained; the pug is subjected to extrusion, curing, drying, cross-linking, alcohol soaking and other processes, and finally a modified nano-hydroxyapatite bone tissue engineering scaffold is prepared. Preparation of the scaffold has the advantages that the process is simple and controllable, raw materials are low in cost, finished products are free of heavy metal pollution, and the production period is short. According to the modified nano-hydroxyapatite bone tissue engineering scaffold prepared through the method, cell experiments show that cytotoxicity is qualified, degradation experiments show that the scaffold has good degradation performance and has certain bioactivity, mechanical experiments show that the scaffold has good mechanical properties, and accordingly industrial production is expected to be achieved to achieve clinical application.
Year: 2016
Country: CN
Doc No: 105963789