23 Jul METHOD FOR MANUFACTURING HYALURONATE FIBERS BY USING MELT SPINNING AND HYALURONATE FIBERS MANUFACTURED THEREBY
Abstract
Provided is a hyaluronate fiber, and more particularly to a hyaluronate fiber, suitable for use in a surgical suture, a filler for cosmetic surgery, a lifting thread, a tissue-engineering scaffold, etc., and a method of manufacturing the same. Further, a method of manufacturing the hyaluronate fiber through melt spinning is provided, which includes (a) controlling the water content of a hyaluronate having a weight average molecular weight of 500 ̃3,000 kDa to 5 ̃20%, (b) producing a hyaluronate fiber by placing the hyaluronate having a controlled water content in a melt-spinning apparatus and performing heating to 150 ̃200° C. and then high-pressure spinning, and (c) hardening the surface of the hyaluronate fiber by immersing the hyaluronate fiber in an ethanol aqueous solution.
Year: 2018
Country: US
Doc No: 2018243471