23 Jul Method for improving de-cellular system engineering valve/blood vessel stent
Abstract
The invention discloses a method for linking a RGD improved acellular tissue engineering valve/intravascular stent with epoxy chloropropane. The method, by using epoxy groups of the epoxy chloropropane, cross links and fixes the functional domain RGD (YGRGDSP) polypeptide of cell adhesion and recognition receptors on an acellular tissue engineering valve/intravascular stent material; meanwhile, the chemical crosslinking function of the epoxy chloropropane can fully cross link the collagen protein which is the main component of the acellular stent material so as to achieve the purposes of anti-calcification and reducing the zymolysis speed inside the stent material, and finally proving the improved acellular tissue engineering valve/intravascular stent with better biological and mechanical properties, higher adhesion rate toward seed cell, and better property of delaying enzyme digestion and anti-calcification, therefore, the acellular tissue engineering valve/intravascular stent can actually meet the requirements of tissue engineering valves.
Year: 2009
Country: CN
Doc No: 101385870