23 Jul Method for improving blood compatibility of microcapsule
Abstract
The invention discloses a method for improving the blood compatibility of a microcapsule, which comprises the following steps in sequence: adopting colloidal micella as a template, and assembling polyelectrolyte with opposite charges on the surface of the micella by a layer-upon-layer static self-assembly method to obtain a colloidal micella with a core-shell structure; grafting polyethylene glycol (PEG) or bovine serum albumin (BSA) on the outmost layer of the micella or carrying out electrostatic adhesion on the BSA; and then removing the template by a dissolving or decomposing method to obtain a polyelectrolyte hollow microcapsule. Through testing the anticoagulant plasma recalcification time (PRT), whole blood clotting time (CT) and the hemolysis performance of various microcapsules, the blood compatibility of the microcapsule is proved to be greatly improved, thus providing good conditions for the application of the microcapsule in the fileds of biological materials, drug delivery, tissue engineering and the like.
Year: 2010
Country: CN
Doc No: 101785764