23 Jul Method for constructing tissue engineering skin
Abstract
The invention relates to a method for constructing tissue-engineering skin. The construction method adopts an autocrine extracellular matrix of fibroblast as a biological scaffold of the tissue-engineering skin. The method utilizes the extracellular matrix excreted by the cultured fibroblast as the biological scaffold and human epidermal cells as seed cells, and the cultured tissue-engineering skin is closer to the structure of natural skin. The method has the advantages that: firstly, the method is simple and convenient, and favorable for synthesis and mass production of products because thematerials take the form of liquid; secondly, the obtained product has the structure which is closer to the natural skin, and the method is favorable for improving the sensibility and the precision ofprediction of the toxicity of compounds; thirdly, the product does not contain additional biomaterials, so that the risk of cross infection of zoonosis cannot occur; and fourthly, the obtained product is convenient for quality control, so that the variation between batches is reduced.
Year: 2009
Country: CN
Doc No: 101485905