23 Jul Method and special equipment utilizing spin accumulation method to prepare tissues and organs
Abstract
The invention relates to a method and special equipment utilizing a spin accumulation method to prepare tissues and organs, and belongs to the technical field of tissue engineering. Based on a core dissolving technology and a cell assembly technology, various cell growth factors, inhibitors or medicines are compounded into a cross-linkable/polymerized hydrogel material, filamentous hydrogel extruded from nozzles is crosslinked/polymerized and compositely synthesized into a polymer solution, is washed by a culture solution and then is wound and accumulated on a rotary inner core, the hydrogel containing various types of seed cells and the hydrogel to which endothelial cells and nerve cells are adhered respectively form a main body part and a blood vessel and nerve system, the inner core is dissolved after completion of forming and the tissue and organ with spiral blood vessels and nerves are obtained after culturing for a period of time. The method and the special equipment provided by the invention are simple in process and easy in forming of the blood vessel and nerve system, and is especially suitable for forming the tissue and organ with a lumen difficultly formed by the traditional tissue engineering, and the prepared tissue and organ can be applied to a damaged tissue and organ or directly transplanted in vivo to replace the damaged tissue and organ.
Year: 2014
Country: CN
Doc No: 104207859