23 Jul Medicament coating material and preparation method
Abstract
The invention relates to the field of vascular tissue engineering, in particular to a medicament coating material which can be used in vascular tissue engineering and intervened in a stent and a preparation method. The coating material has the characteristics of degradability and an effect on promoting the growth of endothelial cells and inhibiting platelet adhesion. The coating material takes a polymer material which has good biocompatibility as a medicament carrier, and takes an effective extracts such as ferulic acid and derivatives thereof of a traditional Chinese medicament angelica sinensis. The preparation method has the following processes of: fully dissolving the medicament carrier and a medicament with a solvent; and using after mixing uniformly by ultrasonic sound. The medicament coating material can be prepared by a solution pouring method, wherein uniformly dissolved solution is poured in glass ware; volatilizing the solvent for 24 hours at the temperature of between 20 and 25 DEG C in vacuum to form a film; continuing heating for volatilizing the solvent thoroughly for 48 hours; and sterilizing for later use. The coating material has the effects on inhibiting the platelet adhesion and prompting the growth of endothelial cells, and can be used in the field of vascular tissue engineering and intervened in a degradable medicament coating on a stent surface.
Year: 2011
Country: CN
Doc No: 101934093