23 Jul MATRIX FOR PRODUCING LIGAMENT, TENDON, AND OTHER TISSUE BY TISSUE ENGINEERING
Abstract
PROBLEM TO BE SOLVED: To provide a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. ;SOLUTION: The invention provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed. ;COPYRIGHT: (C)2010,JPO&INPIT
Year: 2010
Country: JP
Doc No: 2010075717