23 Jul Macroscopic supermolecule-assembled 3D ordered tissue engineering scaffold and preparation method thereof
Abstract
The invention discloses a macroscopic supermolecule-assembled 3D ordered structure. The prepared ordered structure can be used in a cell induction differentiation template and 3D tissue engineering scaffold materials. The introduced construction elements comprise a plurality of biocompatilbe materials such as polydimethylsiloxane, hydrogel and chitosan. Through a microimprinting method, the above materials and magnetic nanoparticles are pressed into a precast temple so that a lot of the construction elements can be prepared, and the construction elements are subjected to surface modification with specific supermolecule function groups. Through an external magnetic field, the construction elements are accurately positioned in a 3D space and are fixed to designated positions by supermolecule interaction so that 3D ordered structure controllable preparation is realized. Through modification of the appointed construction element surfaces with specific protein recognition sites, needed growth factors are introduced by intermolecular specific identification in implementation so that the specified growth factors are directionally introduced into a 3D support material.
Year: 2015
Country: CN
Doc No: 104841020