23 Jul Liver tissue engineering scaffold degradable in vivo and having physiological blood vessel network structure and preparation method thereof
Abstract
A liver tissue engineering scaffold degradable in vivo and having physiological blood vessel network structure and a preparation method thereof are provided, wherein the scaffold is made of galactosylated chitosan, galactosylated or galactose-modified degradable macromolecular materials. The scaffold is a porous sponge body and has a physiological blood vessel network structure therein. The preparation method comprises the following steps: selecting degradable aliphatic polyester materials to obtain a physiological blood vessel tree model by molding blood vessel; then preparing degradable liver tissue engineering scaffold having physiological blood vessel network structure by a combined method of infiltration forming and lyophilization/filtering technology. The scaffold can cause the vascular endothelial cell and liver cell to grow well in pores of tube in blood vessel network and porous sponge body, which is good for the forming of new blood vessel and demand of the cell number in vivo implanted by the scaffold. The inventive liver tissue engineering scaffold has a good biocompatibility, certain mechanical strength and toughness. The preparation technology is simple and easy to operate.
Year: 2009
Country: CN
Doc No: 101530631