23 Jul Light/temperature double sensitive hydrogel and preparation method thereof
Abstract
The invention discloses a light/temperature double sensitive hydrogel and a preparation method thereof, wherein the temperature sensitive part of the hydrogel is obtained by introducing hydroxybutyl into a chitosan molecular chain (Patent No. 201110214776.X), and the free amino group of hydroxybutyl chitosan and the epoxy group of glycidyl methacrylate are subjected to a ring-opening reaction to introduce a photosensitive group so as to obtain the photosensitive part. According to the present invention, the methacrylylated hydroxybutyl chitosan hydrogel is in a solution state at a low temperature, can be subjected to flowing injection, and can form a hydrogel within 1 min when a temperature is raised to around 37 DEG C; a photoinitiator is added into a prepolymer solution, the obtained solution is exposed to ultraviolet light, and the photoinitiator generates free radicals to initiate methacryloyl-substituted chain polymerization, such that the strength of the gel is significantly enhanced; and the light/temperature double sensitive hydrogel has good application prospects in the fields of tissue engineering scaffolds or drug sustained-release delivery and the like.
Year: 2019
Country: CN
Doc No: 110407954