23 Jul Layer-by-layer-self-assembling small-caliber tissue engineering blood vessel and establishing method thereof
Abstract
The invention relates to a layer-by-layer-self-assembling small-caliber tissue engineering blood vessel and an establishing method thereof. The method mainly comprises the steps that chitosan/beta-cyclodextrin nano slow-release particles are established, and wrapping endothelial progenitor cells are mobilized to capture molecules; natural biological materials or artificial synthetic materials are knitted into artificial blood vessels in an electric spinning method, or decellularization homologous or heterogeneous blood vessels are used; and tissue engineering blood vessel surface modification is carried out, and a layer-by-layer-self-assembling mode is used for modifying molecule nano particles captured and mobilized by wrapping adenosine, receptor stimulant thereof and the like to a biology artificial blood vessel support. The artificial blood vessel can be established conveniently, releasing of medicine can be effectively controlled, medicine sudden releasing can be lowered, and meanwhile good mechanical property and clinic practicability are achieved. Blood vessels of any caliber can be established, and in-vivo induced circulation blood endothelial progenitor cells mobilization and homing can be carried out. Artificial blood vessel endothelialization can be promoted quickly, and meanwhile hemadostenosis and blocking caused by smooth muscle cell pathologic proliferation can be restrained for a long time.
Year: 2015
Country: CN
Doc No: 104783923