23 Jul Keratin fiber-nerve growth factor composite stent of nervous tissue engineering
Abstract
The invention discloses a keratin fiber-nerve growth factor (NGF) composite stent of nervous tissue engineering and a preparation method thereof. The preparation method for the keratin fiber-nerve growth factor composite stent of the nervous tissue engineering comprises the following steps: processing keratin fibers by using acidic solution, breaking an epidermal layer on the topmost surface, andexposing an internal cortical layer, to obtain the processed keratin fibers; enabling a nerve growth factor to be loaded on the processed keratin fibers, to obtain the keratin fiber-nerve growth factor composite stent. The provided composite stent can be used for remarkably promoting the survival of neural stem cells and increasing a proportion of the neural stem cells differentiated as nerve cells and an expression number of acceptors Trk A. So the NGF-keratin fiber can be used as a novel three-dimensional stent. The composite stent is capable of providing a new method and idea for treating nervous system injuries or diseases by using a nervous tissue engineering method.
Year: 2018
Country: CN
Doc No: 108525007