23 Jul Islet cell microcapsule for tissue engineering and preparation method of microcapsule
Abstract
The invention belongs to the field of medical bioengineering, and relates to an islet cell microcapsule for tissue engineering and a preparation method of the microcapsule. The method adopts the structure of sodium alginate-active amino component-polyethylene glycol, the inner layer of the structure is coated with sodium alginate modified by arginine-glycine-aspartic acid peptide, and then polylysine coupled with hyperbranched polyethyleneimine is taken as a stabilizer, wherein the hyperbranched polyethyleneimine performs crosslinking reinforcement on the polylysine layer to improve the mechanical property of the microcapsule; and the outermost layer of the microcapsule is composed of polyethylene glycol segments which are unilaterally fixed on active amino components, due to the sliding performance of the polyethylene glycol segments, the microcapsule has an inhibitory effect on the adhesion of proteins and cells; as polyethylene glycol is a material tending to be ‘invisible’ in a human body, and thus the microcapsule can inhibit fibrosis to a certain extent, so that the survival time of active cells is prolonged; and the microcapsule can improve the blood sugar level of type 1 diabetes patients to a certain extent.
Year: 2019
Country: CN
Doc No: 110251731