23 Jul Intelligent hydroxybutyl chitosan hydrogel stent based on 3D printing technology and preparation method thereof
Abstract
The invention discloses an intelligent hydroxybutyl chitosan hydrogel stent based on the 3D printing technology and a preparation method of the intelligent hydroxybutyl chitosan hydrogel stent based on the 3D printing technology. The intelligent hydrogel, thermo-sensitive hydroxybutyl chitosan, which is of a single system and has high responsiveness to temperature and ion strength is adopted, the feature that sol-gel phase change is caused by the temperature and the ion strength of the thermo-sensitive hydroxybutyl chitosan is utilized, and the formed hydrogel stent is obtained through adjustment and control over the temperature and 3D printing parameters; then, through inorganic-salt-induced phase change, the hydrogel stent is evenly shrunk, and the mechanical strength and the precision of the hydrogel stent are further improved. The intelligent hydroxybutyl chitosan hydrogel stent based on the 3D printing technology overcomes the defects that 3D printing hydrogel is generally poor in formability, low in mechanical strength, low in precision and the like. Compared with existing common methods of adopting photosensitizer, complex-system hydrogel and the like, the intelligent hydroxybutyl chitosan hydrogel stent based on the 3D printing technology does not need introducing of any photosensitizer or cross-linking agent, is simple in system and gentle in technology; and the prepared 3D stent has high mechanical strength and is provided with a precise internal structure, and the prepared 3D stent can be widely applied to tissue engineering and tissue repair of the cartilage, the skin, the vessel, the nerve, the myocardium and the like.
Year: 2017
Country: CN
Doc No: 106552287