23 Jul Inorganic/organic diphase nano composite bone tissue engineering scaffold and preparation method thereof
Abstract
The invention discloses an inorganic/ organic diphase nano composite bone tissue engineering scaffold and a preparation method thereof. The bone tissue engineering scaffold is prepared by adopting an in-situ bionic method and a nano self-assembly technology; chitosan, chondroitin sulfate and hyaluronic acid are used as organic media; a soluble calcium salt and a soluble phosphate are used as precursors of inorganic phase nano hydroxyapatite; and by simulating bio-mineralization and adopting a mode of controlling the growth of the inorganic phase through organic macromolecules, the inorganic/ organic diphase nano composite bone tissue engineering scaffold, namely the nano hydroxyapatite/ chitosan/ chondroitin sulfate/ hyaluronic acid bone tissue engineering scaffold, is prepared on the organic matrix through in-situ nucleation and crystallization. The preparation method is simple and mild in process conditions; and the prepared composite scaffold is similar to a natural bone on macro and micro, and is excellent in performance and convenient to form and process.
Year: 2013
Country: CN
Doc No: 102973980