23 Jul Injectable silk fibroin bone repair filling sustained-release material, and preparation method and application thereof
Abstract
The present invention provides an injectable silk fibroin bone repair filling sustained-release material, including oligomeric lactic acid grafted strontium-doped hydroxyapatite and a silk fibroin dehydration compound and genipin, wherein the molar content of strontium in the oligomeric lactic acid grafted strontium-doped hydroxyapatite is less than 10%. The present invention also provides a preparation method thereof, comprising the steps of: obtaining oligomeric lactic acid grafted strontium-doped hydroxyapatite, wherein the molar content of strontium in the oligomeric lactic acid grafted strontium-doped hydroxyapatite is less than 10%; mixing the oligomeric lactic acid grafted strontium-doped hydroxyapatite and a silk fibroin solution with a mass concentration of 1-10%, heating to 30-70 DEG C, reacting for 4 h to obtain a mixture; mixing the mixture with a genipin aqueous solution with a concentration of 1-15% to obtain the injectable silk fibroin bone repair filling sustained-release material. The present invention also provides the application of the injectable silk fibroin bone repair filling sustained-release material in tissue engineering and drug delivery.
Year: 2013
Country: CN
Doc No: 103041447