23 Jul Injectable self-repairing hydrogel based on polysaccharides, preparation method and application of hydrogel to biological tissue engineering
Abstract
The invention discloses injectable self-repairing hydrogel based on polysaccharides, a preparation method and application of the hydrogel to biological tissue engineering, and belongs to the technical field of high polymer materials. The method includes the steps of modifying natural high polymer chitosan so that the defect that the chitosan can only be dissolved in acid solutions can be overcome and the dissolubility of the chitosan in water can be improved; conducting mixing reaction on the chitosan and a modified sodium hyaluronate derivative solution, delaying the reaction time or raising the temperature so that sol can be converted into gel and hydrogel can be endowed with the injection characteristic and the self-repairing characteristic. It is shown through cell co-culture experiments that the intelligent hydrogel has the advantage of high biocompatibility, degradability and the like. The injectable self-repairing hydrogel as a novel medical high polymer carrier material has potential biological and medical application value when used for the co-culture together with cells, protein, DNA, antigens and other active substances, and even the delivery, release and other aspects of medicine and other in-vitro substances.
Year: 2016
Country: CN
Doc No: 106009003