23 Jul Injectable polyglutamic acid chemical crosslinking hydrogel and preparation method thereof
Abstract
The invention discloses an injectable polyglutamic acid chemical crosslinking hydrogel which is characterized in that modified polyglutamic acid or polyglutamate is prepared as a first component; modified polysaccharide macromolecules (such as alginic acid, hydroxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, chitosan and the like), a modified polysaccharide mixture, modified synthetic macromolecules (such as polypropylene glycol, poly(o-hydroxy butylene), polyacrylic acid, polyglutamic acid and the like), modified gelatin, modified collagen and the like are used as second components; the two components are mixed in a certain proportion; and an injectable polyglutamic acid chemical crosslinking hydrogel is prepared through a Schiff base reaction, wherein the gelling time is 10-600 seconds. The hydrogel disclosed by the invention has the advantages of good mechanical performance, excellent biocompatibility and biodegradability and broad application prospect in the fields of tissue engineering, medicine controlled release, regenerative medicine and the like.
Year: 2013
Country: CN
Doc No: 103146002