23 Jul Injectable hydrogel and preparation method and application thereof
Abstract
The invention discloses injectable hydrogel and a preparation method and application thereof. The injectable hydrogel is composed of a raw material A, a raw material B and gelling liquid, a mass sum of the raw material A and the raw material B accounts for 5-50% of mass of the hydrogel, the raw material A is butyraldehyde-polyethylene glycol-butyraldehyde, and the raw material B is four-arm-terminated amino modified polyethylene glycol. The injectable hydrogel is obtained by mainly utilizing imide dynamic bonds formed by amino of four-arm-terminated amino modified polyethylene glycol and aldehyde of butyraldehyde-polyethylene glycol-butyraldehyde. The injectable hydrogel can be applied as a drug carrier, an embolization material or a tissue engineering material. The preparation method includes steps: adding the gelling liquid into the raw material A and the raw material B, and well mixing to obtain the injectable hydrogel. The injectable hydrogel has the advantages of simple, convenient and quick preparation process and easiness in large-scale production.
Year: 2017
Country: CN
Doc No: 107233629