23 Jul Injectable DBM (decalcified bone matrix) hydrogel and preparation method thereof
Abstract
The invention discloses injectable DBM (decalcified bone matrix) hydrogel and a preparation method thereof and relates to a biological tissue engineering technology. According to the preparation method, homogeneous or heterogeneous bone tissue is degreased, decalcified and decellularized, a freeze-dried DBM is prepared, the freeze-dried DBM is digested with pepsin and is cured under the conditions of neutral pH, 37 DEG C and appropriate salt concentration, and the injectable DBM hydrogel is obtained. The DBM hydrogel prepared with the method has good biodegradability, but most importantly, the DBM hydrogel has an injectable property; meanwhile, by means of decellularization processing, the immunogenicity is greatly reduced, the biocompatibility is better, and the biological rejection reaction is reduced; the injectable DBM hydrogel has the advantages of adopting available materials and being convenient to operate and low in cost, can be applied to various bone defect filling and bone graft fusion of min-invasive orthopedic surgery, and has good clinical application prospect.
Year: 2016
Country: CN
Doc No: 106178119