23 Jul Injectable bone cement and preparation method thereof
Abstract
The invention relates to an injectable bone cement and preparation method thereof. The injectable bone cement comprises powder and curing liquid, wherein the powder is composited of calcium sulfate hemihydrate and polyethylene glycol diacrylate, and the curing liquid is sulfhydrylated hyaluronic acid aqueous solution or sulfhydrylated chitosan aqueous solution. The preparation method comprises the following steps of: preparing the powder of calcium sulfate hemihydrate and polyethylene glycol diacrylate inproportion; adding the curing liquid according to the liquid-to-solid ratio of 0.4-1.0mL/g, mixing and stirring evenly, and curing at room temperature to form the injectable bone cement. Sulfhydrylated hyaluronic acid and sulfhydrylated chitosan are liable to form intramolecular and intermolecular disulfide bonds under neutral condition and have higher degree of crosslinking and viscoelasticity; thus, injectable property, collapse resistance and mechanical property of the bone cement are improved. Meanwhile, the bone cement provided by the invention also has good biocompatibility and biodegradablity, and can be used for filling and repair for various bone defects. The injectable bone cement and the preparation method thereof are used in the field of tissue engineering and medicine.
Year: 2015
Country: CN
Doc No: 104645418