23 Jul Hydroxyapatite/biodegradable polyester composite material and preparation method thereof
Abstract
The invention discloses a hydroxylapatite/biodegradable polyester composite material and a preparation method thereof. The preparation method includes the following steps: under conditions of no water, no oxygen, and argon protection, the composite material is obtained by carrying out an in-situ polymerization reaction of hydroxyapatite and an aliphatic cyclic monomer under catalysis of stannous octoate; the aliphatic cyclic monomer is selected form at least one of lactide, epsilon-caprolactone and glycolide; and the composite material provided by the invention comprises hydroxylapatite and a biodegradable polyester. The composite material provided by the invention has the surface enriched with a hydroxylapatite layer having a biological activity, and has an excellent biological compatibility and the biological activity; an biological activity interface can rapidly induce calcium ion deposition in a physiological environment so as to induce nucleation and growth of apatite, and imitates inorganic/organic components of a natural bone matrix in composition; based on the above characteristics, the modified hydroxylapatite/biodegradable polyester composite material is a good support material for repairing bone defects, and has good application prospects in the fields of cell expansion and bone tissue engineering.
Year: 2013
Country: CN
Doc No: 103319696