23 Jul Hydrophilicity modification method of hydroxyapatite single-crystal nanorod
Abstract
The invention discloses a hydrophilicity modification method of a hydroxyapatite single-crystal nanorod. The hydrophilicity modification method comprises the following steps: firstly, synthesizing hydroxyapatite nanocrystalline with the surface modified by oleic acid; carrying out reflux reaction on the hydroxyapatite nanocrystalline with the surface modified by oleic acid and adenosine 5′-monophosphate sodium salt or riboflavin sodium phosphate, according to the mass ratio of 4: 1, in an acetone solvent for surface ligand exchange, so as to prepare a sample A; reacting the sample A with S-isocyanic acid-N-ethyl-N’-phenyl dithiocarbamate, so as to obtain a hydroxyapatite nanocrystalline sample B with the surface modified by a chain transfer agent; carrying out reversible addition-fragmentation chain transfer polymerization reaction on the sample B and a hydrophilic polymer. The hydrophilic nano-hydroxyapatite prepared through the method can be used in medicine carrying and substituting and cell imaging, can be used as an inorganic raw material for preparing degradable biomedical materials, such as artificial bones and bone cement, and has a good application prospect in relevant fields, such as biological materials and tissue engineering.
Year: 2015
Country: CN
Doc No: 105133022