23 Jul Hydrogel material as well as preparation method and application thereof
Abstract
The invention belongs to the field of material preparation and in particular provides an oligopeptide. The sequence of the oligopeptide is (arginine-alanine-aspartate-alanine)4-isoleucine-lysine-isoleucine-lysine-isoleucine-lysine-valine-alanine-valine. The invention further provides a hydrogel material which is formed through preparing the oligopeptide into an oligopeptide water solution and carrying out self-assembling; the material is formed by connecting a plurality of acidic and alkaline amino acids on the basis of an RADA16-I sequence through a non-covalent bonding effect. The hydrogel material prepared by the invention has a function of promoting nerve cell axon extension and nerve regeneration; the material has good biocompatibility, and in-situ loading cells/active molecules and in-vivo in-situ injection can be realized; the hydrogel material has remarkable effects on the nerve regeneration and repairing and has wide application prospect and clinical value in the fields of three-dimensional culture of cells including nerve cells, tissue engineering bio-scaffold materials and medicine carriers.
Year: 2017
Country: CN
Doc No: 106397545