23 Jul Human monoclonal antibody against TGF-beta type II receptor and medicinal use thereof
Abstract
Various human monoclonal antibodies that bind to human TGF-beta type II receptor to inhibit the signal transduction of human TGF-beta signal into cells are produced by immunizing human antibody-producing transgenic mice generated by genetic engineering techniques with the soluble human TGF-beta type II receptor. Further, these human monoclonal antibodies were demonstrated to be effective for preventing and treating various diseases induced by human TGF-beta in various organs (for example, tissue fibrosis).
Year: 2009
Country: US
Doc No: 7579186