23 Jul HUMAN MONOCLONAL ANTIBODIES AGAINST TGF-BETA II RECEPTOR AND MEDICINAL USE THEREOF
Abstract
Various human monoclonal antibodies that bind to human TGF- beta type II receptor to inhibit the signal transduction of human TGF- beta signal into cells are produced by immunizing human antibody-producing transgenic mice generated by genetic engineering techniques with the soluble human TGF- beta type II receptor. Further, these human monoclonal antibodies were demonstrated to be effective for preventing and treating various diseases induced by human TGF- beta in various organs (for example, tissue fibrosis).
Year: 2002
Country: EP
Doc No: 1245676