23 Jul HUMAN MONOCLONAL ANTIBODIES AGAINST TGF- beta II RECEPTOR AND MEDICINAL USE THEREOF
Abstract
Various human monoclonal antibodies which bind to human TGF- beta II receptor and thus inhibit the signal transduction of human TGF- beta into cells are obtained by immunizing human antibody-producing transgenic mice constructed by using genetic engineering techniques with the human TGF- beta II receptor. Further, it is found out that these human monoclonal antibodies are efficacious in preventing and treating various diseases induced by human TGF- beta in various organs (for example, tissue fibrosis).
Year: 2001
Country: WO
Doc No: 136642