23 Jul Host-guest supramolecular hydrogel, and preparation method and application thereof
Abstract
The invention discloses a host-guest supramolecular hydrogel, and a preparation method and an application thereof. The host-guest supramolecular hydrogel is prepared through initiating the copolymerization of free radicals by host-guest supramolecule and methacrylic anhydride gelatin (GelMA) under an ultraviolet light (UV ) condition, and has good mechanical strength and biocompatibility. The host-guest supramolecule is prepared through the host-guest coupling of acryloyloxyethyl isocyanate-modified beta-cyclodextrin (beta-CD) and allyl 1-bromoadamantane. Compared with pure GelMA hydrogel, thehost-guest supramolecular hydrogel has the advantages of good mechanical properties, control of the mechanical strength of the hydrogel by adjusting the concentration of the host-guest supramolecule,and good biocompatibility. The host-guest supramolecular hydrogel also has the advantages of simple preparation process, mild conditions, effective improvement of the mechanical strength, and good application prospect in the field of tissue repair engineering.
Year: 2018
Country: CN
Doc No: 107652452