23 Jul High-strength medical hydrogel based on humanized collagen and preparation method thereof
Abstract
The invention discloses a high-strength medical hydrogel based on humanized collagen and a preparation method thereof. The method comprises the following steps: taking sodium periodate as a selectiveoxidizing agent for performing open-loop oxidation on beta-cyclodextrin to prepare dialdehyde beta-cyclodextrin, using lysyloxidase for crosslinking the humanized collagen to prepare enzymatic self-crosslinking humanized collagen, adding the dialdehyde beta-cyclodextrin in the enzymatic self-crosslinking humanized collagen, and taking molecular self-assembly as a gel construction method to preparethe high-strength medical hydrogel based on humanized collagen. The high-strength medical hydrogel based on humanized collagen has good biological compatibility, biodegradability and biological safety, has good mechanical strength, and can be used as a haemostasis material, a tissue engineering scaffold, a high-grade dressing material, and a drug carrier material.
Year: 2018
Country: CN
Doc No: 108210985