23 Jul High-strength degradable cartilage tissue engineering scaffold and preparation method thereof
Abstract
The invention discloses a high-strength degradable cartilage tissue engineering scaffold and a preparation method thereof. The high-strength degradable cartilage tissue engineering scaffold is formed by compounding chitosan and gelatine in weight ratio of 1:(0.01-2), wherein mass percent concentration of chitosan is 3-6%, and mass percent concentration of gelatine is 0.03-10%. The preparation method of the high-strength degradable cartilage tissue engineering scaffold is characterized in that natural biological materials such as chitosan and gelatine are adopted as raw materials, an in-situ precipitation and freeze-drying method is adopted for preparing a chitosan-gelatin compound porous scaffold which has excellent mechanical performance, controllable degradation rate and excellent biocompatibility, is not added with a crosslinking agent and is composed of pure natural biological materials. The chitosan-gelatin compound porous scaffold has the advantages that a degradation period can be regulated according to proportional relation between gelatine and chitosan, and growth rate matching probability of regenerated tissues is improved; and experiments verify that human cartilage cells can be well adhered and propagated on the surface of the materials.
Year: 2015
Country: CN
Doc No: 104721881