23 Jul Heparinized bacterial nanocellulose/chitosan composite tube and preparation method and application thereof
Abstract
The invention relates to a heparinized bacterial nanocellulose/chitosan composite tube and a preparation method and application thereof. The heparinized bacterial nanocellulose/chitosan composite tube has a 3D fiber network structure; chitosan is deposited on the surface of a nanofiber and in a network; and heparin is grafted on bacterial nanocellulose and the chitosan. The preparation method comprises the steps of putting the pretreated bacterial nanocellulose BNC into a chitosan CH acid solution for oscillation, immersing the bacterial nanocellulose BNC into an alkaline solution for standing and cleaning to obtain the BNC/CH composite tube; and putting the BNC/CH composite tube into a buffer solution for oscillation and putting the composite tube into a heparin Hep cross-linking system for oscillating and cleaning to obtain a BNC/CH-Hep composite tube. The mechanical property is strengthened, the heparinized bacterial nanocellulose/chitosan composite tube has a better anticoagulation effect, thrombosis is prevented, adhesion, multiplication and growth of cells are facilitated, and meanwhile, the chitosan is capable of achieving slow release of the heparin through degradation in a body and maintaining higher vascular patency rate, and has great potential in application in the field of tissue engineering, such as an artificial blood vessel, an artificial trachea, a nerve conduit and a catheter.
Year: 2017
Country: CN
Doc No: 107376015