23 Jul GROWTH FACTOR COMPLEX AND MODULATION OF CELL MIGRATION AND GROWTH
Abstract
PROBLEM TO BE SOLVED: To provide isolated protein complexes including a growth factor, e.g. insulin-like growth factor (IGF)-I, IGF-II, vascular endothelium growth factor (VEGF) or platelet-derived growth factor (PDGF), or at least domains of the growth factor that enable binding to and activation of both a growth factor receptor, and an integrin receptor-binding domain of vitronectin or fibronectin. ;SOLUTION: The protein complexes may be in the form of oligo-protein complexes or single, synthetic proteins where the growth factor and vitronectin or fibronectin sequences are joined by a linker sequence, in the case of a single synthetic protein. In particular forms, vitronectin or fibronectin sequences do not include at least any of a heparin-binding domain and a polyanionic domain. There are provided uses of these protein complexes for stimulating or inducing at least any of cell migration and/or proliferation which may have use in wound healing, tissue engineering, cosmetic and therapeutic treatments, e.g. skin replacement and skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, there is provided inhibition of cancer cell metastasis, particularly in relation to breast cancer. ;COPYRIGHT: (C)2011,JPO&INPIT
Year: 2011
Country: JP
Doc No: 2011120595