23 Jul Gelatin-based reverse gel crystal hydrogel three-dimensional bracket, preparation method and application thereof
Abstract
The invention relates to a gelatin-based reverse gel crystal hydrogel three-dimensional bracket, a preparation method and an application thereof. According to the invention, a template micromanufacturing technique and a high-concentration light-induced crosslinking methacrylamide gelatin solution are utilized to manufacture a protein-based three-dimensional bracket with uniform pore interconnection, structure stability and adjustable degradation property. The gelatin-based reverse gel crystal hydrogel three-dimensional bracket can supply excellent cell attachment site and better intercellular interaction of liver cells, has the potential of serving as effective artificial liver platform for screening drugs and also has the potential of a multifunctional platform for same tissue engineering purpose and in vivo application. According to the invention, a highly ordered protein-based inverse opal hydrogel with biological degradability and uniform pore connectivity is prepared; the highly ordered protein-based inverse opal hydrogel can be used for biological application, such as, three-dimensional biological printing, three-dimensional cell culture, drug screening and in vivo transplanting; the gelatin-based reverse gel crystal hydrogel three-dimensional bracket is simple, controllable, regeneratable and economical.
Year: 2017
Country: CN
Doc No: 107041969